The researchers from Duke University have developed a bone bandage that gathers pro-healing adenosine molecules to fast track bone repairing.
Fremont, CA: Bone fracture is one of the most complex and challenging injuries that result in a prolonged and sometimes incomplete repair. A way of approaching new treatments for bone fractures includes delivering new bone cells, which can endorse healing. Still, the delivery of these cells is limited due to challenges imposed by high costs and limited engraftment of transplanted cells. The Duke University research team developed a method to mobilize bone tissue as an alternate approach, to boost its healing abilities with the help of an exceptional biomaterial.
The research team stated that the body produces a high amount of adenosine molecules, post bone injuries, and gaining increasing access to it can help augment the bone repair. The quantity of natural adenosine can be limited, leading to insufficient repair. The bone bandages were discovered to sequester adenosine molecules to the area of bone injury. A polyethylene glycol (PEG) network, which is functionalized with boronate molecules, is used to bind adenosine and gradually release it over time.
To evaluate the potential of this approach, the researchers enforced it in a mouse model with tibia fractures. The team witnessed that the mice treated with the therapeutic bandages were healing faster than the ones without the boronate molecules. Three weeks later, it was observed that the mice with therapeutic bandages had higher healing than those without, displaying better bone formation, higher bone volume, and better vascularization.
Adenosine is omnipresent all over the body at low levels, and it performs numerous essential exercises that have nothing to do with bone healing. In order to avoid the unwanted side effects, the researchers had to search for a way to keep the adenosine localized to the affected tissue at appropriate levels. They have concluded that this is a feasible approach and filed a patent for future devices and treatments. The bandages can be engineered to seize and hold on to adenosine more efficiently. Additionally, they also have to find out if these results hold in humans or have the probability of causing any side effects.