The latest researches make way for next-gen materials that actively work to drive wound healing with the help of tissues.
FREMONT, CA: There has been a rise in performing surgical procedures in the U.S., which simultaneously also gives a push to the number of surgical site infections. Certain wounds like the chronic ones that do not heal quickly in cases of diabetes and often surface the wound with a wide range of bacteria in the form of biofilm. Biofilm bacteria, as such, are very tough to treat, and the antimicrobial resistance only triggers the possibility of an infection in the wound.
As per some recent statistics from multiple sources, chronic wounds tend to affect over 5 million people approximately in the U.S. A few chronic wounds might end up in amputations, which is the case in diabetic ulcers. On the other hand, researchers predict a chronic, non-healing diabetic ulcer leads to an amputation every 30 seconds.
Looking at the situation, there is a desperate need of innovative as well as effective wound healing techniques. Scientists feel positive in this regard, as they have devised a molecule that can help in harnessing the natural healing process of the body. Those molecules are known as traction force-activated payloads (TrAPs), the growth factors that contribute materials like collagen to interact with the tissues in the body naturally.
Materials like collagen are mostly used to heal wounds. For example, collagen sponges can be used to treat burn injuries, and its implants can help in regenerating bones. When it comes to interacting with tissues, in the supposed scaffold implants, the cells move throughout the collagen structure along with pulling the scaffold. The method then triggers the healing proteins, which are the growth factors helping in regenerating tissues.
Moreover, the TrAP molecules can also be engineered to recreate the natural processes. Several experiments revealed that the cells dragged the TrAPs along with them as they started moving through the collagen implants, leading to the activation of growth proteins that boost the healing process within the tissue. The technique explains that the method recreates healing processes persisting all-round-the natural world. Furthermore, the approach imitates them and actively works with different varieties of cells that form on the damaged tissue eventually, to help in healing.