A Modern Approach to Chronic Pain Management
By MedTech Outlook | Friday, November 30, 2018
In order to treat severe chronic pain, the excessive use of opioids has resulted in escalated death rates. Since then, there has been a requirement for non-addictive and effective medicines with minimum or no side-effects. The co-director and founder of the Chronic Pain Research Consortium at Duquesne University, Jelena Janjic is a patient of the severe chronic syndrome herself. She has researched the delivery of non-opioid medication with the patient’s immune system. The medicine is supposed to be embedded in nanoparticles and injected into the patient. In 2010, Janjic was on pain relieving medication since she was diagnosed with chronic pain syndrome. As she began to experience side effects, she wanted a remedy that didn’t involve opioids. After conducting some research of her own, she discovered that inflammation leads to pain, which occurs due to an underlying injury. The immune cells in the area of inflammation are the most active. By stimulating the nerve cell, pain increases at that particular site. In the case of chronic pain syndrome, the intensity and location of pain vary, and that’s the primary reason behind no effective medication.
Previously, Janjic was conducting research on Cancer nanomedicine. The anti-cancer drug was embedded in nanoparticles and injected in patients which targeted the immune cells showing positive results. From this research, she convinced the researchers to make similar pain-relieving medication. The in-vivo experiment first conducted on rats turned out to be successful by injecting anti-inflammatory and non-steroidal drugs, which reduced the pain in rats.